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Watson and Holmes is a comic book series that features Sherlock Holmes and John Watson as African Americans in New York City's Harlem district. The story was a modern urban take on the Sir Arthur Conan Doyle stories and had Watson take a lead role, as emphasised by the title.

Watson was an Afghanistan war veteran and worked in an inner-city clinic; Holmes was a local P.I. who took unusual cases. When one of them ended up in Watson's emergency room, the unlikely duo struck up a partnership to find a missing girl. Watson and Holmes bumped heads along the way as they entered a labyrinth of drugs, guns, and gangs, and a conspiracy that went higher and deeper than they could have imagined.